TMS Therapy - A Breakthrough in Treating Depression
By Mehboob Ali Nazarani, M.D.
Published December 6, 2024 · Last reviewed December 6, 2024 · 3 min read · Depression
TMS Therapy - A Breakthrough in Treating Depression
For individuals struggling with depression, especially those who haven't found relief through traditional treatments, Transcranial Magnetic Stimulation (TMS) offers new hope. This innovative therapy is revolutionizing the way depression is treated, providing a safe, non-invasive, and effective option for many.
Let's explore what makes TMS therapy a game-changer.
What is TMS Therapy?
TMS is a non-invasive treatment that uses magnetic fields to stimulate specific areas of the brain involved in mood regulation, particularly the left dorsolateral prefrontal cortex (DLPFC). This area often shows reduced activity in individuals with depression.
Key Features of TMS:
- Non-Invasive: No surgery or anesthesia is required.
- Drug-Free: TMS doesn't rely on medications, making it ideal for individuals who experience side effects from antidepressants.
- Outpatient Treatment: Sessions are conducted in a clinic setting, with no downtime required.
- Customizable Protocols: The treatment is tailored to each individual's needs, ensuring optimal results.
How Does TMS Work?
TMS therapy works by delivering targeted magnetic pulses to stimulate neurons in areas of the brain associated with mood and emotional regulation. Here's a step-by-step breakdown:
- Preparation:
- The patient sits comfortably in a chair.
- A magnetic coil is placed gently on the scalp, near the forehead.
- Stimulation:
- The coil delivers painless magnetic pulses to the brain.
- These pulses stimulate underactive regions of the brain, enhancing neural activity.
- Duration:
- Sessions typically last 20–40 minutes.
- A typical course of treatment involves daily sessions (5 days per week) over 4–6 weeks.
- Post-Treatment:
- Patients can resume normal activities immediately after each session.
Why is TMS a Breakthrough?
1. Effective for Treatment-Resistant Depression
TMS has been shown to significantly improve symptoms in individuals who haven't responded to traditional treatments. Studies report:
- 30–40% remission rates for treatment-resistant depression (TRD).
- Even higher response rates for individuals with less severe depression.
2. Safe and Well-Tolerated
Unlike medications, TMS doesn't have systemic side effects such as weight gain, nausea, or drowsiness. Side effects, if any, are usually mild and may include:
- Scalp discomfort during the session.
- Temporary headaches.
3. Focused on Mood Regulation
TMS directly targets the brain's mood-regulating regions, making it more precise than traditional therapies that affect the entire body.
4. Evidence-Based Success
TMS is FDA-approved for major depressive disorder (MDD) and backed by robust clinical studies and real-world outcomes.
5. Durable Results
Studies show that the benefits of TMS are long-lasting. Up to 62.5% of patients who respond to acute TMS therapy maintain clinical improvements over 12 months, with retreatment options available for symptom recurrence.
Who Can Benefit from TMS Therapy?
TMS is particularly beneficial for individuals who:
- Have not responded to two or more antidepressants (TRD).
- Experience intolerable side effects from medications.
- Are seeking a non-pharmacologic approach to treating depression.
- Want to avoid invasive treatments like electroconvulsive therapy (ECT).
Advantages of TMS Over Other Treatments
TMS vs. Medications
- Targeted Approach: Unlike medications, which affect the entire body, TMS directly stimulates specific brain areas.
- Minimal Side Effects: No systemic issues like gastrointestinal discomfort or hormonal changes.
TMS vs. ECT
- Non-Invasive: No need for anesthesia or hospitalization.
- No Cognitive Side Effects: TMS doesn't cause memory loss, a common concern with ECT.
Is TMS Right for You?
If you or a loved one is struggling with depression that hasn't improved with traditional treatments, TMS could be the next step. A mental health professional can help determine if this therapy is suitable based on your medical history and current condition.
Take the First Step Toward Relief
TMS therapy represents a breakthrough in depression treatment, offering hope to those who feel like they've run out of options. With its safety, effectiveness, and non-invasive nature, TMS is helping individuals regain control of their lives.
To learn more about TMS and how it can help, visit our TMS page below:
If you are ready to consider TMS therapy, we are here to help. Schedule a consultation to learn more about how TMS can help you overcome depression and take the next step.
This article is part of our approach to whole-person psychiatric care. If this resonates with your experience, our team is here to help.

Mehboob Ali Nazarani, M.D.
Board-Certified Psychiatrist
Mehboob Ali Nazarani, M.D.
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